Non_healing Ulcers
Chronic ulcers or non-healing ulcers are defined as spontaneous or traumatic lesions, typically in lower extremities that are unresponsive to initial therapy or that persist despite appropriate care and do not proceed towards healing in a defined time period with an underlying etiology that may be related to systemic disease or local disorders.
There are many types of non-healing ulcers that may include venous, arterial, diabetic, pressure and traumatic ulcers. The normal wound healing process is dynamic and complex having three phases: inflammation, tissue formation and tissue remodeling.
However, if the normal healing process is interrupted, an ulcer can become chronic in nature due to lack of growth factors and cytokines which delay the healing process . Lower extremity ulcers comprise a substantial proportion of chronic ulcers, especially those attributed to venous disease, diabetes, or arterial disease . Chronic non-healing ulcer is a major health problem
